First, the sequence determinants of origin function seem to spread out over a much longer sequence.
Yet little is known about the genetic determinants of origin replication times or firing efficiencies.
By acquiring virulence determinants of foreign origin, commensals can evolve into pathogens.
This may be interpreted by considering that humanised Trastuzumab maintains at the antigen-binding site structural determinants of mouse origin, which engender a poor fit with the rat antigen, a negative feature, which is not shared by the human antigen-binding structure of Erb-hcAb.
These data requirements and aspirations for comprehensive participant populations are essential as CV-GPS seeks to identify new determinants of the origin of CVD and, more important, factors that can be translated into new and improved diagnostic and treatment pathways for CVD.
Although skeletal muscle is the major disposer of dietary glucose and a major determinant of glycemia, the origin and consequence of muscle inflammation in the development of insulin resistance are poorly understood.
Even though it has been shown that both Rif1 and the yeast Ku protein (Yku) are required for the late replication of yeast telomeres [ 11, 12], it remains unclear how telomere length acts as a determinant of the timing of origin firing.
Several determinants control the timing of origin firing, including the chromatin environment and epigenetic modifications.
Among these inhabitants, immigrant-related determinants other than country of origin, fluency in Dutch and level of education may have an effect on the level of compliance with occlusion therapy.
To analyse the association between self-perceived discrimination and social determinants (social class, gender, country of origin) in Spain, and further to describe contextual factors which contribute to self-perceived discrimination.
