Sentence examples for determinant of lifetime from inspiring English sources

Linking the genetic and stem cell models of cancer, a recent study proposed that the accumulation of mutations through stem cell divisions is a major determinant of lifetime cancer risk (Tomasetti and Vogelstein, 2015).

The reason for this is that the life expectancy of a patient on ART is a key determinant of lifetime costs and of the number of patients surviving and remaining in care over any projection period; it is therefore one of the most important inputs into any estimation of the costs of scaling up.

Offspring number is one of the key determinants of lifetime reproductive success [ 34], and reduction in this trait is very likely to result in fitness costs.

Peak bone mass (PBM), which is achieved by early adulthood, is a key determinant of the lifetime risk of osteoporosis.

Together these findings indicate that in cells basal hydrolysis is an important determinant of Rab5 lifetime and turnover.

Current opinion holds that the genetic makeup of an individual is likely to be a major determinant of the lifetime predisposition to sepsis, and progress continues to be made in identifying relevant candidate genes [ 20, 35].

Even if all the measurements are accurate, the author's statement " in cells basal hydrolysis is a more significant determinant of Rab5 lifetime and turnover than GAP-mediated turnover" is highly speculative.

Our initial focus on ADA3 stemmed from the well-accepted role of the hormonal history of a woman as a determinant of her lifetime risk of developing breast cancer [ 4]: the well-established pro-oncogenic role of estrogens in animal models [ 5, 6] and the linkage of environmental estrogens to increased risk of breast and other cancers [ 4].

Insights into the determinants of enzyme lifetime and product yield are providing generalizable cues for engineering heme-dependent proteins to further broaden the scope and utility of these non-natural activities.

Psychiatric disorder was the main determinant of 12-month and lifetime suicidal ideation and lifetime suicide attempts across all geographical regions.

Although these initial findings were limited to premenopausal women, postmenopausal IGF1 levels may also be an important determinant of breast cancer risk if considered as a component of lifetime or intratissue exposure.