Sentence examples for determinant of differentiation from inspiring English sources
To rule out non-specific effects of depolarization and determine whether control of transmembrane potential is an instructive, bi-directional determinant of differentiation trajectory, we next asked whether hyperpolarization affected differentiation.
If Vmem is a true determinant of differentiation potential, as has been suggested [43], hyperpolarization ought to have the reverse effect of depolarization and thus induce differentiation.
Crucially, our functional results show that the relationship between depolarization and an undifferentiated state is not merely a correlation but rather that transmembrane potential is a functional determinant of differentiation state in hMSCs.
Because hyperpolarization treatments caused an opposite effect to the depolarization treatments (depolarization suppresses differentiation, while hyperpolarization increases differentiation), our data support a view of membrane potential as an instructive determinant of differentiation state.
Because this critical role can be disrupted by the opposing effects of AHR repression, inhibition, or ligand-mediated activation, it is reasonable to conclude that the level of functional AHR during cardiomyogenesis is a critical determinant of differentiation.
Contributing to the challenge of understanding these mechanisms in both of these sensory systems is the size of the receptor families and understanding other molecular determinants of differentiation and axon targeting in main olfactory and vomeronasal sensory neurons.
A well-established cascade of transcription factor (TF) activity orchestrates adipogenesis in response to chemical cues, yet how cell-intrinsic determinants of differentiation such as cell shape and/or seeding density inform this transcriptional program remain enigmatic.
Receptor activator of NF-κB ligand (RANKL) is a type II transmembrane protein found on osteoblasts which functions as a major determinant of osteoclast differentiation and activation.
Objective: The Sox9 transcription factor has emerged as an important determinant of chondrocyte differentiation, including the regulation of type II collagen (Col2) and aggrecan gene expression.
Taken together, these data suggest that the endogenous hyperpolarization is a functional determinant of hMSC differentiation and is a tractable control point for modulating stem cell function.
The encoded protein is used as a determinant of lymphocyte differentiation.
