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A cell-extrinsic mechanism of 1d fate restriction undoubtedly operates in more basal gastropods, where the D cell inherits neither a polar lobe nor any other determinant of developmental potential at second cleavage [52].
Human behavior and molecular genetic data suggest that genetic makeup acts as a crucial determinant of developmental outcome.
Although CMV can be transmitted to the fetus even if there is preconceptional maternal immunity, reinfection or reactivated latent infection might be an important determinant of developmental and intellectual impairment in the offspring.
Via comparisons to previously identified caste-related genes, we found that nourishment restriction only partially biased wasp gene expression patterns toward worker caste-like traits, which supports the notion that nourishment, in conjunction with social environment, is a determinant of developmental caste bias.
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Proteins involved in regulation of chromatin structure can therefore act as important determinants of developmental processes.
Nonetheless, we envision that the identification of cohort-specific parameters to define human embryo phenotypes is a necessary step towards translational investigations of molecular determinants of developmental competence.
Collectively, our results indicate that embryos from a cohort share as yet undefined genetic or epigenetic determinants of developmental competence, which is consistent with the greater increase in implantation relative to pregnancy rates conferred by blastocyst transfer [37].
Adverse pregnancy outcomes are well-established determinants of developmental delays and disability in children [ 8].
The NLSCY dataset consists of long-term, population-based survey data collected since 1994, and is designed to evaluate the determinants of developmental outcomes of Canadian children and youth.
The NLSCY dataset consists of long-term, population based survey data collected since 1994, and is designed to evaluate the determinants of developmental outcomes in Canadian children.
The EDI and linked parental questionnaires are promising indicators of the extent, distribution and determinants of developmental vulnerability among children in their first year of primary school in Ireland.
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