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Among the determinants of mortality in hematology patients with ARF, mechanical ventilation remains the major determinant of death [1, 4], as well as the type of ARF etiology (e.g., Invasive aspergillosis) [1, 5], poor performance status, allogeneic bone marrow stem cell transplantation, delayed ICU admission [6] or associated organ dysfunction [1, 3, 7].
Diabetes was also demonstrated to be an independent determinant of death in the general population suffering from ICH [ 12].
This is likely to reflect the influence of what is known to be the strongest determinant of death at home - hospital availability and use [ 15].
While a key 2007 paper made the case for ROS, specifically hydroxyl radicals, as a common determinant of death induced by diverse antibiotics, three recent papers presented data inconsistent with this model.
The recent identification in India that smoking (and perhaps indoor air pollution) might be a key determinant of death from tuberculosis demonstrates that environmental hazards can play an often hidden but critical role in human health.
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In the early 1990s, when mortality was highest, inadequate access to insulin was likely the major determinant of deaths.
The covariates identified as determinants of death in the primary analyses were entered into the model.
Conclusion: These data suggest that for patients not weaned from the IABP, the major determinants of death are low cardiac output (33.3%) and multiorgan failure (47.6%).
On one hand, this could suggest that requirements of RBC transfusion, presumably imposed by persistent tissue dysoxia, could represent a very potent prognostic factor even when adjusted to the classical determinants of death in this setting.
Tuberculosis is a leading cause of death worldwide, yet the determinants of death are not well understood.
Prognostic factors were evaluated by using Cox proportional hazards regression analysis to estimate adjusted rate ratios while adjusting for other potential determinants of death.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com