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It may be therefore that impaired corticospinal output, rather than lesion location per se, is the primary determinant of altered excitability in the distributed cortical network.
As discussed in Response 4, deeper intronic RNA sequencing could identify additional RBM47-dependent splicing events, which could also reveal links to mRNA stability, but based on current data, alternative splicing does not seem to be a major determinant of altered mRNA stability in the context of RBM47.
Acidosis emerged as the prime determinant of altered sensorium, but hyperosmolarity played a synergistic role in patients with severe acidosis to precipitate depressed sensorium (odds ratio 2.87).
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Vav2/Vav3-deficient mice should serve not only as a useful murine model of spontaneous glaucoma, but may also provide a valuable tool in understanding of the pathogenesis of glaucoma in humans, particularly the determinants of altered aqueous outflow and subsequent elevated intraocular pressure.
We believe that Vav2/Vav3-deficient mice will serve not only as a useful murine model of spontaneous glaucoma, but may also provide a valuable tool in understanding of the pathogenesis of glaucoma in humans, particularly the determinants of altered aqueous outflow and elevated IOP.
In a large multicenter study conducted in 40 Spanish ICUs and including 725 patients receiving either enteral or parenteral nutrition, Grau et al. showed that overfeeding (> 27 kcal/kg) was one of the determinants of altered hepatic function [ 22].
Malignant transformation of tumour cells is associated with abnormal glycosylation, resulting in expression of altered carbohydrate determinants including the expression of sLex and sLea antigens [ 4, 9, 12].
[ 1- 3] Malignant transformation is associated with abnormal glycosylation, resulting in expression of altered carbohydrate determinants, such as the Sialyl Lewis x (sLex) antigen.
In Antirrhinum [ 10], petunia and maize [ 7, 11, 12], allelic diversity of certain MYB genes are key determinants in the inheritance and segregation of altered anthocyanin distribution.
Altering the environment might be the main determinant of change in enabling childrens' participation.
The identification of or, at least, the estimate of which of the independent hemodynamic determinants is altered makes the therapy a logical consequence.
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