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This shows that the major determinant for the evolution of the additive variance, and thus the evolvability, is directional epistasis.
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The relevant rates of these different mutational processes that shape pathway topology, and the distribution of such topologies in the topology space emerge as the key determinants for the evolution of modularity.
Our results suggest that intrinsic exonic features (relative position and length) may be important determinants for the evolution of A. thaliana coding exons, and that CpG methylation may play different biological roles in the coding exons of mammals and Arabidopsis species.
The biological significance is about the relative role between the functional importance in the biological system of a gene (gene pleiotropy) and the sequence-structure feature for the protein stability: Which one is the major determinant for the rate of protein evolution?
Pleiotropy is also a key determinant in the evolution of antibiotic resistance.
Simpson devised his own special blend of "evolutionary determinants" to account for the rapid evolution underlying the abrupt appearances of new, higher taxa.
Of course, if the conformation is the same, then only the determinants convey the information; while if there are no determinants, the protein conformation is solely responsible for the evolution of the various prion strains.
Lipids played a determinant role in the evolution of the brain.
Physico-genetic determinants in the evolution of development.
These differences in hepatocyte function are also likely to be important determinants in the evolution of liver injury.
All these elements have implications for the evolution of the labour force structure and on the dependency ratio which is a key determinant to the viability of PAYG systems—such as the spanish one.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com