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The fact that Lactococcus lactis expressing LukS-PV signal peptide showed enhanced adhesion suggests that the signal peptide-binding determinant could be likely the N-acetylglucosamine moiety or the wall-associated polymers, common features of Gram-positive bacteria.
Another possible determinant could be the medical characteristics of the populations studied.
One potential determinant could be the statistical method used to analyze the study findings.
This determinant could be the set of telomeres that are differentially segregated among the spores in meiosis (Walmsley and Petes 1985).
Thus, expression of the Tn determinant could be the result of glycosyltransferases deregulation via changes in enzyme activity and/or in substrate specificity [ 40].
The difficulty in classifying offspring and consequent variable segregation ratios have led several authors to conclude that more than one genetic determinant could be involved, although some evidence favours a major gene (Ru).
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Major determinants could be shared locality or values (e.g., "kin-based" and various forms of voluntary as well as "natural" associations as evident in Chilea community).
However, absence of known markers does not necessarily indicate that the virus is benign and previously unrecognized molecular determinants could be responsible for transmission among humans.
Two additional possibilities related to avidity and frequency of MPER-IgMa interactions, (but functionally independent of the interacting allotypic determinants), could be invoked.
Certain specific molecular markers predictive of adaptation to human were found to be absent in the pandemic H1N1 2009 (H1N1pdm) viruses suggesting that, previously unrecognized molecular determinants could be responsible for the transmission among human [7].
Other determinants could be the difference in educational level and occupational status of the mothers in both areas with the urban mothers being more educated and having higher occupational status than the rural mothers.
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