The observation that the bias determinant at the 3′ end of URA3 is influencing ARS1 S without preferentially affecting its efficiency relative to that of ARS1 N (Brewer and Fangman 1994) led us to the hypothesis that the determinant causes the bias by advancing ARS1 S activation time.
The genetic determinants causing variations in virulence and transmissibility have not yet been elucidated.
The major drawback of these studies is the potential for reverse causation (i.e., diabetes or its early determinants causing low vitamin D status rather than vice versa).
Health problems and current life demands were the most common external determinants causing non compliance to EGD; yet when patients were asked in specific, for a reason of inconvenience to endoscopy these factors were impressively diminished.
For example, a program addressing economic barriers should also consider social status and gender since it likely that intermediary determinants caused by theses are closely linked to the intermediary determinants that the program is targeting.
Thus we cannot conclude with certainty that these determinants cause poor access to health facilities and the association of age and travel time to health facility can be partly due to unmeasured or residual confounding.
The data analysis will be carried out by subgroups according to the time of occurrence of the preterm birth and its determinant cause (spontaneous preterm labor, prelabor rupture of membranes, and therapeutic preterm birth).
This suggests immunosuppression might be a determinant cause of VL in these patients, related to the use of immunosuppressors, hemodialysis, post-transplant infection, malnutrition and donor incompatibility, especially in cases of deceased donors [ 11, 32, 33].
If the bias determinant were causing a delay in the activation of ARS1 N, then deletion of the bias determinant should have no effect on the time of activation of ARS1 S and the two plasmids should replicate at the same time.
