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To further determine which sequences within the 90-bp SmaI- HaeIII fragment contribute to bias determinant activity, this fragment was examined by scanning site-directed mutagenesis.
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Specifically, compounds (18 20), which carry a phenyl at position N3 of heterocyclic ring, were the most active ones, suggesting that this is a structural determinant for activity.
It was also a determinant of activity index (AI) that is ratio of concentrations of IL-1β and IL-1RA in GCF, known to correlate with Vt [24],[35],[35],[35].
ROM after TKA is an important determinant of activity level and knee function [ 3].
Here we have performed a structure-activity analysis to identify determinants of activity and selectivity.
Important structural determinants for activity with azathioprine were recognized by means of primary structure analysis and activities of purified enzymes chosen from the screening.
These findings confirm that stabilization of β-turns and a relatively larger ring size are essential determinants of activity for cyclic α-MSH analogs.
However, to design effective strategies for increasing children's PA levels, effects on, and determinants of, activity levels need to be well understood.
The present study investigated protein uptake by cells as a determinant of ES activity.
It has been reported that, cellular glutathione level is an important determinant for the activity of anti-cancer agents [11].
Deprived socio-economic status of Muslims can be considered as a key determinant of entrepreneurial activity as observed in the case.
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