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The pathological basis of this purported white matter deterioration with ageing, which occurs in the absence of overt white matter changes such as hyperintensity on T2 imaging, is not well delineated, but Bartzokis [ 34] has suggested that dysfunction of oligodendrocytes and the myelin sheaths they maintain may be to blame.
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In our results, measurement of both high and low frequency vibration detection thresholds on proximal body sites also indicated a progressive deterioration with aging.
The accumulation of the mtDNA deterioration with aging could be particularly high in the SNn (Reeve et al., 2013), which normally presents a high number of delections (>40% in healthy sixty-year-old subjects) (Bender et al., 2006).
miRNAs are probably important not only for the ontogenic differentiation of the DAn (Junn & Mouradian, 2012), but also for its deterioration with aging and PD (Kim et al., 2007; Harraz et al., 2011; Mouradian, 2012).
Study of the integrity of aged worms has uncovered a stochastic element to the deterioration associated with aging (Herndon et al., 2002).
The finding comes only a week after scientists in Boston reported using the same genetic engineering technique to identify a gene associated with Alzheimer's disease, a general mental deterioration associated with aging.
Furthermore, it can induce cell death and senescence, leading to functional deterioration, associated with aging.
These findings strongly suggest that J147 might be lowering the AD-related pathology in old SAMP8 mice by preventing some of the deterioration associated with aging.
His area of expertise is plant growth and development, especially the role of hormones, and the regulation of the senescence (deterioration with age) of whole plants.
This paper demonstrates how this same methodology can be employed in the field of biomedical engineering to optimise the design and whole life performance of implants considering factors such as (i) deterioration with age, and (ii) stochastic variation in load.
Instead, we predicted that wild shrews would demonstrate only limited responses to parasites, and that their immune system would show signs of deterioration with age.
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CEO of Professional Science Editing for Scientists @ prosciediting.com