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The aim of these retrospective informant interviews (RINI) was to gather details of any incident conditions or deterioration relevant to the final diagnosis formulated after brain examination.
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For interpreting the effectiveness of the treatment, we must consider not only statistical significance but also whether the improvement (or deterioration) is relevant for the patients or clinicians.
The time to event (i.e. "survival") approach based on the time to HRQoL score deterioration is relevant in the event of a quicker alteration of patients' HRQoL in one treatment arm as compared to the other, and if this difference is maintained over time (risk proportionality).
No patient experienced clinically relevant deterioration in disease parameters measured.
At the heart of this framework is the choice of an appropriate combination of models for the relevant deterioration processes and the uncertainty associated with these models and their input variables.
In the paper, after a general presentation of the main properties and of the most relevant deterioration phenomena of the principal parts of the monumental area, the methodology that is being used for the structural diagnosis, for the implementation of guidelines for the future interventions and for the maintenance of the restored conditions are presented.
Clinically relevant deterioration (≥0.5) was observed in 9.8-12.3%.
The percentage of patients with a clinically relevant deterioration from baseline was analysed by χ-tests.
Systemic hemodynamics, as a measure of safety, showed no relevant deterioration throughout the procedure.
Consequently, we classified a ≥0.6 increase in DAS as a (clinically relevant) deterioration.
No patient showed clinically relevant deterioration in ophthalmological parameters after ASA404 treatment.
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CEO of Professional Science Editing for Scientists @ prosciediting.com