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The liver is the predominant site of phenylalanine metabolism; therefore, deterioration of liver function, indicated by abnormally high levels of aminotransaminases (ALT, AST, and GGT), may decrease phenylalanine metabolism, thereby increasing its systemic level.
It is characterized by inflammatory, progressive destruction of the biliary system leading to liver fibrosis and progressive deterioration of liver function.
These results suggested that hAMCs transplantation ameliorates the CCl4-induced deterioration of liver function.
In both groups, no patients had deterioration of liver function, history of esophageal variceal bleeding or an introduction of a beta-blocker therapy during the period of monitoring.
Massive apoptosis and/or necrosis cause deterioration of liver function.
Patients with refractory AIH had severe deterioration of liver function.
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ALF is a severe liver disorder with devastating consequences and it encompasses a pathophysiological response associated with rapid deterioration of liver functions.
We considered hepatic failure, hepatorenal syndrome, veno-occlusive liver disease, hepatic encephalopathy, and the increase of blood bilirubin as the deterioration performances of liver function.
In recent decades, some authors [ 23] have considered the presence of PVT to be a contraindication for TACE due to the risk of liver function deterioration and hepatic infarct [ 24] but patients with PVT may not present technical and safety contraindications to TACE if a selective/superselective procedure is performed [ 20, 25].
The VEGF protein levels were increased with the improvement of liver function, and the AFP protein levels were increased with the deterioration of the liver function after BMSCs transplantation.
Blood and liver tissues were collected for evaluation of liver function and liver fibrosis indicators.
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