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In other persons, blood vessel damage is early and severe, coupled with serious deterioration of heart function.
There were 4 deaths (14% of 29 patients with follow-up), and 7 complications (pulmonary embolism, 1 case; hemiplegia, 1 case; subsequent deterioration of heart function, 5 cases).
Recent data demonstrated that fat-feeding of C57Bl/6 male mice results in deterioration of heart function [35].
This mechanism could contribute to deterioration of heart function in diabetes.
Inadequate angiogenesis, microvascular and cardiomyocyte dysfunction, scar formation, and insufficient perfusion via the collateral coronary arteries will lead to deterioration of heart function [ 3].
This vicious cycle causes a change in heart structure as well as hemodynamic abnormalities, leading to irreversible deterioration of heart function [ 45].
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Altena et al (2009) showed deterioration of diastolic heart function assessed with echocardiography ∼10 months after chemotherapy.
Moreover, the patients that survive heart injuries experience, at best, progressive deterioration of their heart function unequivocally leading to HF [ 2].
By performing cardiac magnetic resonance imaging (MRI) before and again after chemotherapy, the authors found a significant deterioration of diastolic heart function secondary to cisplatin-based therapy.
A previous study showed progressive deterioration of diastolic heart function, 10 months and 6.9 years after cisplatin-based chemotherapy (Haas de et al, 2013).
Peroneal F-wave persistence and amplitude in addition to tibial nerve F-wave persistence and heart-rate response to standing were significantly reduced in the benfotiamine group, which may indicate a slight deterioration of nerve function.
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