tBHP treatment of SH-SY5Y cells for 16 h caused a significant deterioration of cell membrane integrity resulting in leakage of cytoplasmic LDH into the media.
Carbon corrosion due to high voltages encountered during the operation of fuel cells and the accompanying deterioration of cell performance are among the main issues affecting the durability of fuel cells.
Because the volume changes are not expected to occur during a potentiostatic hold (referred to as calendar-life aging), by comparison of cycle-life and calendar-life aged cells one can expect to assess the role of volume changes in the deterioration of cell performance.
The absence of significant deterioration of cell viability (80% for labeled vs. 87.5% for unlabeled BMCs, P>0.05), as indicated by the Trypan blue dye exclusion test, suggests that the radioactivity detected in the supernatant is secondary to 99mTc leakage from labeled BMCs rather than cell death.
Aging involves a deterioration of cell functions and changes that may predispose the cell to undergo an oncogenic transformation.
At siramesine concentrations below 20 μM a slow cell death occurred, which was probably associated with progressive deterioration of cell homeostasis due to defects in multiple processes, including lysosomal degradation, autophagic flux, intracellular trafficking and energy metabolism.
It is well established that, in virtually every biological system, aging, i.e., the progressive deterioration of cell, tissue, and organ function, can be delayed through calorie or dietary restriction.
CEM level increases are responsible for the deterioration of cell deformability, which affects the lifespans of circulating erythrocytes, and this results in greater cellular turnover and elevated RDW values [ 82– 82].
