However, contrary to our findings, the ADOPT study showed a continued increase in insulin sensitivity in both groups after the first 6 months, whereas in TODAY, there was continued and comparable deterioration in insulin sensitivity in all three groups.
Further deterioration in insulin sensitivity or secretion may enhance the risk for this progression.
Khanal et al. [ 9] reported that deterioration in corneal sensitivity and tear physiology was seen immediately after phacoemulsification.
Previously, we reported that rising alanine transaminase levels in obese children and adolescents were associated with deterioration in insulin sensitivity and glucose tolerance (30).
Yet there is evidence that anti-VEGF therapy is also effective in reducing the deterioration in contrast sensitivity (CS), another measure of visual function.
Over 24 weeks, 10 g/day inulin-propionate ester supplementation significantly reduced weight gain, intra-abdominal adipose tissue distribution, intrahepatocellular lipid content and prevented the deterioration in insulin sensitivity observed in the inulin-control group.
It has been reported that a modest weight reduction achieved via caloric restriction resulted in a 13% deterioration in insulin sensitivity among a group of postmenopausal MHO women (2).
However, whether aspirin has a net beneficial contribution to glucose homeostasis has been controversial, with several studies suggesting that any favorable hypoglycemic action is offset by deterioration in insulin sensitivity (23, 24).
The direct trauma caused by the forceps when gripping the ILM may not be the main cause of all these microscotomas, because first, operations were performed by experienced surgeons (RT, AG, PM) accustomed to exercise caution when peeling off the ILM, and second, because the deterioration in retinal sensitivity was too diffuse to be explained by a direct retinal trauma.
Using a genetic mouse model that mirrors partial pharmacological inactivation of p110α, we found that sustained p110α attenuation protects from fat accumulation and deterioration in insulin sensitivity upon ageing and leads to better overall glucose homeostasis compared with control aged mice.
Finally, no special care is required for electrode storage; the present Ag/α Fe2O3-modified GCE showed unique storAg/α Fe2O3-modified weeks with almost no surface deterioration or reduction in sensitivity.
