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As shown in the several representative experiments, a considerable degree of enhancement and the restoration of the deteriorated visual information can be achieved by the proposed SR algorithm.
However, some, who already had significantly deteriorated visual fields, understood that their therapeutic window had passed.
None of these cases developed into graft failure or deteriorated visual acuity, so no treatment was administered.
Since progression of retinal pigment epithelium (RPE) atrophy is common in the natural history of PCV [ 9, 10] and photodynamic therapy (PDT) [ 30, 31], progression of RPE damage during the long-term follow-up period of therapy in eyes with PCV may result in deteriorated visual function.
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Both test scores declined with increasing age, earlier school leaving age and deteriorating visual acuity.
In contrast, the proposed method may deteriorate visual appearance of the enhanced images since the resulting images of the proposed method have a compressed dynamic range with high local contrast that might cause an unnatural image appearance.
Cousin III-5 had had a gradually deteriorating visual acuity since his thirties to 0.05 at age 64 years.
Other authors [ 16, 18] did not find differences between patients with stable and deteriorating visual fields for the CRA.
With respect to family 2, the proband developed color vision disturbances at age 16 years, and a progressively deteriorating visual acuity since age 43 years to counting fingers at age 75 years.
In our family with Danon disease, two of the four affected males presented with all features of CRD: a progressively deteriorating visual acuity, severe color vision disturbances, a central visual field defect on perimetry, and reduced photopic and scotopic responses on ERG.
None had intra-operative difficulties that required them to later wear glasses, post-operative complications necessitating a refractive correction, or concomitant ocular diseases at the time of surgery deteriorating the visual acuity prognosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com