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They suggested that capsaicin-induced coronary artery spasm in the rat heart was mediated by endothelin release from sensory nerve terminals, resulting in deteriorated cardiac function.
STZ-induced diabetic animals suffer from deteriorated cardiac function with increased myocardial infarction following I/R.
At the same time, therapy optimization has also resulted in an increased incidence of HF, since patients survive with severely deteriorated cardiac function [ 13].
During the chronic cardiac remodeling process with interrupted leptin signaling, the heart transforms from compensated to decompensated states accompanied by deteriorated cardiac function.
Again, we observed a deteriorated cardiac function with EF 19.9% and FS 8.9% in Rnd3+/− haploinsufficient mice after TAC.
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She was admitted to the ICU because of a severely deteriorating cardiac function.
In addition, intramyocardial injection of Wnt3a following MI impedes endogenous cardiac regeneration and deteriorates cardiac function [ 86].
However, a sustained rapid ventricular response may further deteriorate cardiac function [ 5], accelerating the symptoms of heart failure [ 6– 8].
Many hospital admissions among aged patients with CHD can be attributed to behavioural and social factors rather than to deteriorating cardiac function or an intercurrent cardiac event [ 13].
26– 39 Progressive decline in nutritional status is linked with active and poorly controlled disease, and deteriorating cardiac function, morbidity and mortality.
The ischaemic heart also loses its metabolic flexibility and can switch to glucose or fatty acid oxidation as its preferential state, which may deteriorate cardiac function even further in case of type 2 diabetes mellitus.
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