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Zhang, Z. et al. Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer.
The purpose of the study was to evaluate the benefit of care guided by the detection of stage B heart failure (SBHF) using advanced echocardiography for the reduction of new HF in the community.
Following our analysis plan, we selected from the 45 resulting classifiers one with the highest overall performance of pre-specified criteria (Table 5), including discrimination of NSCLC from controls, detection of Stage I disease, and detection of cancer in chronic obstructive pulmonary disease (COPD).
This is not entirely surprising as detection of Stage 1 types can be problematic [ 35].
Sensitivity for detection of stage I AD ranged from 33-50% and stage I SQ was 64-93%.
Table 3 shows that Serologic screening contributed to detection of Stage I tumors by identifying a subpopulation with 7.5 times higher risk of NPC than the general cohort (Table 3).
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Because this could preclude the detection of stage-specific evolution, we then re-analyzed our data keeping only the genes that were expressed at one stage.
Sensitivity for detection of stages II-IV ranged from 51-79% for AD and 82-84% for SQ.
Data on the detection of stages III and IV prostate cancer were based on 332 743 randomised participants.
A major strength of our classifier is the sensitive detection of early stage tumors, and in particular Stage I SQ.
Sensitivity for detection of GOLD stage 1 was 83% and for GOLD stages worse than 1 it was 91%.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com