The different techniques applicable for DNA sequencing, their limit of detection and shortcomings have recently been described.
However, Bi et al. recently presented evidence for the value of chromosome studies in conjunction with CMA to maximize the detection of mosaicism, citing the shortcomings of CMA in detecting low levels of mosaicism (<10%) for either abnormal or normal cell lines, and the presence of two or more abnormal cell lines involving the same region.
Zihui Che Xueyun Ji [56] presented a new anomaly detection model based on rough set reduction and HMM on the basis of the analysis of shortcomings of other detection methods these days.
(See further assessment of shortcomings in the detection of misregulated targets of driver TFs in Additional file 1: Tables S9 and S10).
We developed a new approach called antibody detection of translocations (ADOT) that avoids the shortcomings of current techniques.
There are some reports that indicate shortcomings of the detection of COPD in primary care such as underuse of spirometry, in its diagnosis [ 13- 16].
Unfortunately, biologists have yet to overcome the many experimental limitations for the large-scale detection of protein complexes, such as the shortcomings of Tandem Affinity Purification (a common wet lab complex detection method) listed in a recent protein complex survey paper [ 6].
It improves on a number of shortcomings of current targeted sequencing methods such as accuracy, CNV detection and cost.
The PCR, like any method based on direct detection of the parasite, does have a shortcoming: the amount of specimen processed determines the limit of detection.
found a variety of shortcomings.
