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Electrodes implanted in transplanted porcine livers allow running less invasive monitoring and thus early detection of rejection.
The ultimate aim of the DRAGET project is to replace a strategy based solely on biopsy with one based on a first-line MRI (with biopsy only when needed) for a more efficient and less invasive detection of rejection.
The opinion of the expert physicians of each centre, concerning the confidence they have in the MRI detection of rejection and their wish to use it for the routine follow-up of their patients, will be recorded by questionnaire at the end of the study.
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Such imaging technologies may allow earlier detection of graft rejection and the adjustment of therapies to prolong graft survival posttransplantation.
Accurate monitoring of the chimeric status of patients after stem cell transplantation is essential for early detection of transplant rejection or relapse.
The detection of acute rejection in an early stage is challenging [ 4].
The ability to track cells in vivo will facilitate applications such as detection of tissue rejection, fate mapping of transplanted stem cells, and early detection of cancer.
For the affected patients this would translate into a more timely detection of acute rejection and into fewer renal allograft biopsies, including avoidance of procedure-related complications.
In preclinical and clinical studies labelled leukocytes were utilized for detection of acute rejection in different organs (intestine, heart, skin, or kidney).
Reliable and timely detection of acute rejection in renal transplant patients is important to preserve the allograft function and to prevent premature allograft failure.
Analysis of cfDNA also provides a safer alternative to amniocentesis or chorionic villus sampling for prenatal diagnostics [ 7], or to organ biopsy for the detection of transplant rejection [ 8].
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