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In addition, the proposed biosensor exhibited well specificity for the detection of PSA.
The voltage-controlled intrinsic amplification provided by FEED enabled the detection of PSA contained in serum on the femto-gram/mL level.
The proposed immunosensor exhibited good sensitivity, reproducibility and stability for the quantitative detection of PSA, which hold a great potential in clinical and diagnostic applications.
Under optimal conditions, the proposed immunosensor achieved an ultrasensitive and specific detection of PSA, and displayed acceptable reproducibility, selectivity and stability.
Moreover, the proposed method showed good precision, acceptable stability and reproducibility, and could be used for the detection of PSA in real samples.
In addition, the methodology was validated by analyzing 12 clinical serum specimens, receiving a good accordance with the referenced values for the detection of PSA.
Similar(34)
Results of the ELISA test were correlated with immunohistochemical detection of PSA-NCAM.
Therefore, the threshold of significance for specific detection of PSA-NCAM was set to 10 pg PSA-NCAM/μg of protein.
Using the NiCoBP MWCNT-conjugated aNiCoBP MWCNT-conjugated signanti-PSAduction tantibodyw enzyme-free electrochemicas immunoassay protheol could be designed for the detection of target PSA on the capture antagody-functionalized immunewensing interface.
Excitingly, the phage probe based DPV immunosensor showed high sensitivity for the detection of t-PSA and LOD achieved the pg mL−1 level, which was far lower than those values (usually above 0.1 ng mL−1) for reported immunosensors based on antibodies.
Unfortunately, there are many doubts that, using a traditional clinical approach, we may achieve early detection and treatment of PsA.
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