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Detection of high levels of Cox-2 in dysplasias suggests that overexpression is a marker for intense cell proliferation in early disease (Kuo et al., 2003).
The solid protection observed by C-S8p260 correlated with the detection of high levels of circulating neutralizing FMDV antibodies.
These results were confirmed by the detection of high levels of HIF-1α protein and a strong positive correlation between VEGF and HIF-1α in TAT.
After 48 hrs, a similar pattern of cytokine release was evidenced with the detection of high levels of TNF-α, IL-6, LIGHT, MIP-1α, VEGF, IFN-γ and IL-4.
The detection of high levels of circulating IL-15 is of interest, since this cytokine has been shown to be a major stimulator of NK cells [36] and T cells [37].
The detection of high levels of Serpina3g transcript in lung i.n.n
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In Kaplan Meier analysis, a co-detection of high levels of uPA-T and PAI-1-T or uPAR-T, and of PAI-1-T and uPAR-T, was significantly associated with a shorter OS compared with patients with low antigen levels of the combined markers in tumour tissue (Table 4).
Detection of higher levels of inflammatory cytokines in CD163+ cells than in CD163− cells was unexpected because of the anti-inflammatory role of alternatively activated macrophages [17].
The detection of higher levels of AMP in csgD mutant colonies was consistent with this hypothesis, since AMP is a potent inhibitor of the gluconeogenesis-specific enzyme fructose bisphosphatase (Fbp) [37].
This observation is consistent with the detection of higher levels of HGF/c-MET complex in Ln18 and U87MG cells relative to U138 and U118 cells using the VeraTag FFPE assay format (Fig. 7B).
The discovery of FAST-1 is therefore not surprising in itself, however, the detection of higher levels of FAST-1 in the region showing heterochromatin formation in FRDA patients offers a plausible mechanistic basis for the epigenetic abnormality involving the +1 nucleosome [19] [21].
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