The extent to which these effects of immunogenicity occur relies on several aspects related to the patient, the drug, and detection: the dose, frequency, and administration route of the drug; the timing of the serum sampling; and the complexity of measuring anti-drug antibodies.
In immunoPET, less radiation exposure to bone marrow, improved bone metastasis detection and improved radioimmunotherapy dose planning may be achieved using DFO-cyclo*.
The dose required to evaluate the MIC is therefore critical, as too high a dose will drive parasite numbers below the level of detection and too low a dose will not cure the patient initially.
Importantly, early detection and intervention with high dose Cr supplementation favorably impacts neurodevelopmental outcomes in affected individuals [24].
The model also provided a hypothesis for the lack of a clear dose response for canakinumab in RA, in that the extent of the involvement of IL-1β in the RA disease process, though definitely existent, is not as marked as other cytokines such as tumor necrosis factor-α and IL-6, making the early development detection and characterization of a dose response more difficult.
The γ-H2AX assay is considered to be the most sensitive modern assay for DSB detection and response to radiation doses as low as 1 mGy.
In the article "Natural Variability and the Influence of Concurrent Control Values on the Detection and Interpretation of Low-Dose or Weak Endocrine Toxicities," Ashby et al. (2004) discounted a number of studies reporting low-dose effects caused by endocrine-disrupting chemicals, including bisphenol A (BPA), based on variability in control values in experiments conducted at different times.
Although their detailed description is out of the scope of the present document, useful reference will be provided in the following paragraphs, especially (but not only) for the routine quality control testing of radioactivity detection and measurement instruments, such as dose calibrators, radio-HPLC "flow" detectors and gamma spectrometers.
Both the threshold detection dose and accuracy of measurements depend on the efficiency of energy transformation.
