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These findings suggest that detection and ascertainment bias as well as confounding by indication had a considerable influence on the overall result, which may explain why previous meta-analyses have disagreed in their assessment of the benefit of antiviral therapy.
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The following two subsections "LDLA Haley-Knott type regression" and "Variance components mapping" explicitly present two linear models (Haley-Knott type regression for half-sib families and a general mixed model for a general pedigree) and the statistical tests that lead to QTL detection, location, and ascertainment of the hypothesis linkage, association, both or lack of both.
As with all current CNV detection methodologies deducing copy number variations from SNP data encompasses a number of areas at which error can be introduced and ascertainment biases presented [ 26; 27].
Additional follow-up could also be done later in life for improved serial detection, and combined with administrative records would maximize ascertainment (Calderwood and Lessof 2009).
In addition to increased detection, improving outcome ascertainment and classification is also needed.
The final important source of bias is observer, detection, or ascertainment bias (60).
However, after considering the risk of detection or ascertainment bias the size of the effect was clinically relevant.
Case control definitions and ascertainment.
and potential performance and ascertainment bias.
The NRYPMDR has very good completeness and ascertainment (>98%%) [ 40].
The sampling and ascertainment procedures were described elsewhere [ 20, 21].
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