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The biggest difficulty ESPRIT faces in detecting split genes is posed by the confounding effect of fragments that belong to phylogenetically closely related but distinct paralogous genes.
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Another type of approach to detect "split identities" of web authors is presented in [18].
Ensembl pipeline [ 9] also detects split genes (http://www.ensembl.org/info/docs/compara/homology_method.html), but this approach is not readily applicable to newly sequenced genomes by individual researchers, because it is not yet well documented or available outside the Ensembl pipeline.
He will need to ensure the internal review, and the coming leadership contests, do not add to the impression, confirmed in a BBC poll last night, that twice as many voters see Labour divided as detect splits in the other two parties.
We designed an original DNA probe for detecting NCOA2 split signals on fluorescence in situ hybridization (FISH) and estimated its utility with 20 fibrovascular tumors: 4 each of STAs, solitary fibrous tumors (SFTs), and cellular angiofibromas and 3 each of low-grade myxofibrosarcomas, myxoid liposarcomas, and low-grade fibromyxoid sarcomas.
For example, in a study using a split FISH assay to evaluate 1528 lung cancers, 22 tumors were detected with split RET signals, of which 12 were confirmed as fusions with KIF5B and one with CCDC6 [ 10] and the remaining nine tumors showed little or no expression of the RET kinase domain.
A total of 18 putative chimeric scaffolds (an example is reported in Supplementary Fig. 17) were detected and split.
Harper-Merrett said he detected a "split personality" between the entertainer and the homespun woman.
At K = 3 (Supplementary Fig. S1) and at K = 4 (Fig. 2), we detected a split between Spanish, Balearic and Central West European goats and their African counterparts.
Since Ku, required for the tethering of DNA ends of DSBs, is functional in AT5BIVA and 11-4 cells, we speculate that most of the MLL gene rearrangements detected as split FISH signals are chromosome translocations [26].
In the case of properly selected probes, interphase mpFISH can detect insertion (split signals, Figure 4B).
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