Follow-up and/or treatment will take place depending on the type of detected lesion with a certain probability of success.
Due to energy constraints, we assume that the mobile nodes are kept stationary until a target is detected with certain confidence level, or useful statistics regarding the target locations are available.
However, these mutations might not be detected with certain mutation-specific detection methods (Anderson et al, 2012) and consequently these patients might be excluded from clinical trials with BRAF inhibitors or regular treatment with vemurafenib (Flaherty et al, 2010).
Through extensive simulations, we could determine the probability of detecting transcripts with a certain expression level at a given sampling stage, which provides important implications for future experimental design.
Ritz et al. use all identified CN profiles of an individual to detect breakpoints with a certain probability.
Overall, our results corroborate a previous study that assessed the efficiency and sensitivity of different commercial reverse transriptases, where reverse transcription at high template numbers was efficient for all RTs tested, but low template amounts could not be detected with certain RT systems [10].
However, this type of mutation might not be detected with certain mutation-specific assays [ 7, 33]; consequently, affected patients might be excluded from clinical trials with BRAF inhibitors or regular treatment with vemurafenib [ 16].
What is the probability that a transcript with a given expression level to be detected at a certain sampling depth?
A correct prediction was defined as a simulated true DMR reciprocally overlapped with a detected DMR in a certain proportion of their lengths.
He wrote a play once; the children howled with laughter, but the adults detected a certain lack of gravitas.
