It may be hypothesised that patients with heavy bleeding are more likely to be detected in the first round, which would lead to a decrease in detection rates for repeat screening.
All recombinants detected in the first round of genotyping were subsequently mapped to increased resolution until reaching the maximum hotspot resolution.
With regard to the level of PrPSc detected in muscle tissue, the level estimated from the amplification factor in PMCA was lower than that found in a brain homogenate diluted to 10−6 because no PrPSc signal was detected in the first round of amplification.
Five hundred and thirty eight lesions (45.5%) were detected in the first round of screening and the remainder in subsequent rounds (rounds 2 12).
The former (XXAXSXX) was detected in sequences recovered from the third round of screening, and the latter (XXTHPXX) was detected in the fourth round.
Furthermore, 48.8% of all IC found were detected in the first round and 65.1% at the initial screening.
Physicians should know that patients whose breast cancers are detected in the first round of screening have a higher probability of a better prognosis.
However, it has not been shown that a cancer detected at a round subsequent to one or more screens (incident tumors) has a different biology and outcome from tumors detected in the first round (prevalent tumors) or outside the screening program.
To avoid annotating the same gene twice, the nucleotide sequence of the resulting ORFs was aligned with BLAST [ 35] to the ones detected in the first round of annotation, and ORFs were discarded if the first hit had an E-value < 10 6 and shared 98% identity, or were shorter than 150 bp.
