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Motor symptoms were detected earliest by the accelerating rotarod test, indicating that rotarod performance is the most effective behavioural measure allowing early discrimination between control and CLN6 mice.
A possible founder effect for type 968 is unlikely because the pulsotypes that were detected earliest were mostly low-prevalence types; higher prevalence pulsotypes appeared only later, seemingly outcompeting the low-prevalence types.
Effects of HU have been detected earliest on the viability of osteoblasts [ 3], followed by apoptosis of the osteocytes, activation of osteoclastogenesis and loss in bone mass, attributed to altered mechano-transduction by osteoblasts [ 4].
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Those detected early, his work showed, are often slow-growing and relatively benign.
This one has been detected early, giving health officials what Dr. Chan called a "head start".
He says breast cancers are certainly being detected earlier through the programmes.
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Because too few cases are detected early, it is a common cause of cancer death.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com