A Modified Bromage score(1 = complete block, unable to move feet or knee; 2 = almost complete block, able to move feet only; 3 = partial block, just able to move knee; 4 = detectable weakness of hip flexion; 5 = no detectable weakness of hip flexion while supine with full flexion of knees) was obtained before and epidural insertion and again at hourly intervals.
One person (patient 27, Figure A1) who initially had quadriplegia and respiratory involvement had returned to pre-illness strength and had no detectable weakness on MMT at 1-year follow-up.
Moreover, the presence of clinically detectable muscle weakness was positively associated with the number of days with two or more organ dysfunctions in a multivariate analysis [ 12].
In several other lines, widespread centralisation of myocyte nuclei was seen without detectable muscle weakness, high serum creatine kinase levels or prominent inflammatory infiltrates, demonstrating a muscle phenotype that was not revealed at this stage of the disease by physiological assays.
Studies have reported that the prevalence of detectable lower-extremity weakness ranges from 48% among community-living older persons, 25 to 57% among residents of an intermediate care facility, 26 to more than 80% of residents of a skilled nursing facility.
The GRMD clinical and histopathological phenotype resembles DMD: typically elevated serum CK activity is detectable shortly after birth, weakness is evident within the first few weeks and joint contractures significantly impair movement by 6 months.
Many of these patients have severe weakness which is detectable on the basis of a clinical strength evaluation.
For Fig 6A and B the following disease score was used: 0, no detectable signs of EAE; 1, tail weakness or tail paralysis or hind limb weakness but not both; 2, tail paralysis and hind leg weakness; 3, single hind leg paralysis.
Animals were monitored daily, and neurological impairment was quantified on an arbitrary clinical scale: 0, no detectable impairment; 1, flaccid tail; 2, hind limb weakness; 3, hind limb paralysis; 4, hind limb paralysis and ascending paralysis; 5, moribund or deceased.
Statins are also associated with a chronic myositis syndrome, characterized by muscle pain and weakness with or without evidence of clinically detectable rhabdomyolysis [ 65].
This is suggested because there may be inherent structural weaknesses that are not readily visible or detectable.
