MA is the first clinically detectable stage of involvement of the kidney, and affects between 20 40% of diabetic patients.
These findings suggest that amyloid-based therapies would optimally be targeted at the earliest clinically detectable stage (such as mild cognitive impairment (MCI)) or before.
Aberrant crypt foci (ACFs) may be the earliest detectable stage of colorectal tumorigenesis, and these have been shown to contain methylated sFRP1 alleles (Suzuki et al, 2004).
Reliable estimates of the time it takes pancreatic cancers to progress from its earliest detectable stage to more advanced stages are needed to determine surveillance intervals for patients undergoing pancreatic screening.
These results indicate a clear need for early screening of mild cognitive impairment (MCI) in diabetes patients, as MCI has been suggested to be the earliest detectable stage of AD [ 51].
(E – H ) At the earliest detectable stage of branching, each branch comprised a single apical cell surrounded by leaf initials and was adjacent to one or several developing rhizoids.
Given the role of the mTOR pathway in facilitating the kidney cancer growth, the reduced incidence observed in our study may reflect an effect of sirolimus in preventing small tumors from growing to a clinically detectable stage.
All plants were grown with the following maximum/minimum temperatures and photoperiods: 13°C/7°C, 12 h daylight from emergence to the first node detectable stage, 18°C/10°C, 14 h daylight from then to heading, 20°C/15°C, 16 h daylight from heading to anthesis, and 25°C/20°C, 18 h daylight after anthesis.
Early detection of ovarian cancer might significantly improve the overall survival rate of women with ovarian cancer if 1) most cancers are clonal and unifocal, arising in the ovary rather than in the peritoneum, 2) metastatic disease results from progression of clinically detectable stage I lesions, and 3) cancers remain localized for a sufficient interval to permit cost-effective screening.
Key parameters in the model are the mean duration of the preclinical screen-detectable stages, the sensitivity of the screening test and the improvement in prognosis after screen detection.
