Exact(1)
Exposure of phosphatidylserine (PS) on the cell surface is barely detectable, raising the question whether PS exposure is essential for C1q/WOX1-induced cell death.
Similar(59)
However, reports that early neoplastic lesions can appear before nuclear localization of β-catenin is detectable have raised the possibility that APC regulates additional effectors that contribute to Apc mutant phenotypes in parallel with, but independent of, nuclear β-catenin.
The presence of neurological signs in pigs inoculated with BSE without detectable PrPd raises the possibility that the BSE agent may produce a prion disease in pigs that remains undetected by the current postmortem tests.
Interestingly, in some of these reports, Nodal expression was detected in the context of very low or barely detectable Cripto-1, raising the question as to whether Cripto-1 and Nodal can exert their cancer promoting effects independently of each other [ 17, 26].
What is more, there was no detectable pause between raising the trough and seeing the change in speed.
Preliminary studies on smokers and patients with chronic obstructive pulmonary disease have revealed that several toxic metals and trace elements are detectable in EBC, raising the possibility of using this new matrix to quantify the lung tissue dose of pneumotoxic substances (Mutti et al. 2003).
In addition, a number of studies have demonstrated that DNA methylation may be detectable in urine samples, raising the possibility of detecting epigenetic changes using non-invasive screening methods.
However, our previous analysis at the zebrafish phox2b locus identified numerous functional non-coding regulatory sequences that were not under any detectable constraint [ 29], raising into question the frequency with which current approaches overlook functional elements.
Gait impairments are also observed in diabetic patients without clinically detectable neuropathy [ 3], raising the question of whether it would be worthwhile to test a similar, but more intensive programme on diabetic patients without neuropathy in order to prevent further aggravation of gait and balance.
At different time points, the suppression and reappearance of clones appeared to correlate with timing of drug therapy but the plasma cell leukaemic clone 2.2, which determined patient death, was hardly detectable at the outset, raising clear problems for predictive or prognostic biomarker strategies at diagnosis.
All groups vaccinated with Env expressing DNA plasmids raised detectable but statistically equivalent CD4 T-cell responses (Figure 6C).
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