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The minimum detectable potential in FM-KPFM was more than ten times (more than 20 mV) higher than that detected in HAM-KPFM (approximately 2 mV).
Global alteration in the expression profiles of the 13 detectable potential target genes was consistent with the levels of reduced expression of NOTCH3 itself.
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Figure 9B shows that a discernible, but modest improvement in the fit (and less than 5 mV total separation in the two detectable potentials) is achieved by allowing for breakdown of perfect n = 2e− behavior, represented here by slight broadening of the component features.
Using these criteria and no imposed CSS cut-off, 66 of the 92 known sRNAs were identified as possessing sRNAscanner-detectable potential transcriptional signals (Table S2).
We showed theoretically that the minimum detectable contact potential difference (CPD) in FM-KPFM is higher than in heterodyne AM-KPFM.
Overall, compound A2 was the only one with a detectable inhibitory potential of COX-2 activity whilst two of its ether derivatives demonstrated improved ability in the inhibition of COX-2 expression.
E6 oncogene synergizes with estrogen to induce cervical cancer in only 41% of K14 E6 mice after 9 months, indicating that E6 has a weaker but detectable oncogenic potential in the cervix compared with the E7 oncogene [ 22].
ESTs with no detectable protein coding potential were scanned for repetitive sequences using the BLASTn program.
In the well-known experimental murine model of RRV-induced BA-like disease, where the hepatobiliary disease progresses in the absence of detectable virus, the potential therapeutic use of MAPK blockers could be explored.
Even more satisfying was the observation that in E. coli lysate at a very low RNA concentration of 10 μ m, the two folds were readily detectable, showing the potential of the 2′-SCF3 label for in vivo studies.
Due to the MPSS technology and our stringent criteria for inclusion as a potential antisense detectable tag, only 215/19,794 (1%) MPSS tags could potentially be derived from antisense transcripts (Table 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com