Aggregation of α-synuclein in vivo is believed to be a crucial event in pathogenesis of these diseases, with intermediates (i.e. soluble oligomers) and final products (i.e. larger, insoluble and immunohistochemically detectable aggregates) playing different but equally important roles (1, 9, 10).
There are three different registers detectable in the play.
While peptide residues more than one amino acids away from the 9mer binding core are unlikely to contribute to binding due to excessive flexibility, the +1 and −1 residues could play detectable roles in binding as they share similar flexibility with other core residues.
We show below that matrix resorption and remodeling play no detectable role in shape development, at least during early stages.
Taken together, our data indicate that the CDC27 ubiquitin ligase is essential for F. tularensis to evade lysosomal fusion, while the USP22 ubiquitin-specific peptidase and the PI4KCA PI4 kinase are only required for bacterial proliferation in the cytosol, but play no detectable role in evasion of lysosomal fusion.
Taken together, these results showed that alveolar macrophages, the majority of which assume an alternative phenotype with the induction of Arg1 in response to Aspergillus infection with no detectable expression of NOS2, play an important role in pathogen clearance immediately after fungal infection.
This outcome suggests that the inflammatory response observed in the grafts results from a response of the innate immune system and that the IgM antibodies seen in the immune competent mice did not play a detectable role in intensifying it.
Tests of plant traits indicated that the crayfish responded primarily to plant structure, the apple snails primarily to plant chemistry, and that plant protein concentration played no detectable role.
In a previous study, Faith and Polleck also concluded that transcription plays no detectable role in producing the gradients of asymmetry at redundant sites by separately analysing the four-fold redundant sites in nad6, the only gene transcribed on the minority strand in vertebrate mitochondrial genome [25].
We determined that variations in sap flow also played no detectable role in the magnitude or polarity of the sustained voltage since we mechanically stopped all flow in one experiment by inserting razor blades above and below the length of the electrode and by using severed branches in other experiments.
