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Four purified FP6s were obtained, which had the same molecular mass and different isoelectric points without any detectable modification in the course of purification.
In healthy volunteers, injection of contrast material did not produce any detectable modification in the lung tissue volume calculated using Lungview®, probably because the contrast material remained strictly intravascular in the presence of an intact alveolar capillary barrier and was rapidly eliminated in the urine [ 2].
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Validation of new miRNA targets is often complicated because many putative targets display little or indeed no detectable modification when tested in vitro (Small et al., 2010), and this might account for the relatively modest effect of miR-146a on Fos mRNA levels, despite the huge miR-146a changes observed in transfected cells.
We therefore examined the effect of purified RFC in the presence of multiply primed circular ssDNA at substrate concentrations that yielded barely detectable levels of Siz1-dependent modification in the absence of DNA.
Taken together, our results indicate that the FACS sorting procedure does not introduce any detectable modification of NB properties.
No detectable modifications of pulmonary parenchyma were present in the histology of wild-type, vehicle-, or control siRNA-treated mice (Fig. 3A, a1, a2, a3).
As in the transgenic mice, there are clearly detectable domains of active histone modifications in the LCR and δβ domains indicating that in general the adult β-globin transgene locus has a domain structure similar to the endogenous β-globin locus.
This modification yields no detectable changes in the backbone configuration or ligand topology in the receptor binding cavity, yet it dramatically increases transcription, differentiation and antiproliferation activity of the VDR.
Dimensionality of the feature set has been tremendously enhanced so that the technique is not detectable by minor modification in SPAM steganalyzer.
Although we have shown that Met oxidation represents the major detectable covalent modification during the Photofrin-PDT-mediated inhibition of caspase-3, the role of Met oxidation in this observed inhibitory process still remains elusive.
We documented the extent of ASHM across 23 well-studied histone modifications in the H1 cell line, and found that ASHM is present throughout the human genome and is detectable outside known imprinted regions.
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