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Whether preemptive changes to the treatment regimen in response to early detection of ESR1 mutation(s) and prior to onset of clinically detectable disease progression impacts clinical outcomes is an open question and may need to be addressed in a prospective study.
Even in the absence of detectable disease, the heart undergoes deleterious changes with advancing age.
Recurrent abdominal pain without detectable disease may be a psychosomatic disorder.
Throughout adulthood there is a progressive deposition of cholesterol in the arteries, and the heart muscle eventually grows weaker even in the absence of detectable disease.
The patient was asymptomatic and free of detectable disease at a 6-month follow-up.
Another issue is whether to treat such patients after enucleation, in the absence of systemic detectable disease.
We found another nine cases of ocular TB with no systemic detectable disease and normal chest radiograph, but in three of them strong TST reaction was noted and in a fourth patient non-reacting TST was attributed to pregnancy [1 8].
A feature of the highly virulent isolates was their ability to either cause rapidly fulminant infection within 60 h of challenge, or not cause detectable disease at all.
This retrospective study showed that when using a sufficiently sensitive Tg assay, these patients rarely have a rhTSH stimulated Tg>2 ng/ml and only one of 80 patients had detectable disease.
Thus, until the performance of a candidate marker is evaluated with specimens from women with asymptomatic, early stage cancer, its value as an early detection marker remains hypothetical, and researchers must be cautious not to overstate their claims when assays have only been tested on samples from women with clinically detectable disease [29].
The problem here is defining the criteria for "detectable disease".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com