Unlike their viewpoint [ 4] with glaring omissions, our review [ 1] discusses three scotopic clinical studies showing no clinically detectable disadvantage for blue light-filtering IOLs in scotopic conditions.
These results from independent experiments using different parasite species, indicate that although RON12 is not essential for asexual parasite growth under the conditions used, its absence imparts a detectable disadvantage in these knockout parasites affecting parasite numbers.
Sequence conservation alone is apparently not sufficient to distinguish sequences with critical functions, as large-scale non-genic deletions encompassing highly conserved regions can be tolerated in mice without detectable fitness disadvantages [ 34].
29 However, no disadvantage to mixed-handers was detectable in this study.
For those who have satisfied all the paediatric "milestones", the disadvantage conferred by their prematurity can be subtle, and becomes detectable only when compared against their peers in a classroom situation.
Trace detectable amount is eliminated in urine, giving this molecular marker an edge over serum creatinine's disadvantages.
The disadvantage is that the response of the mode detection algorithm to a single mode is distributed over all detectable modes, similarly to the Point Spread Function of Conventional Beamforming with microphone arrays.
Whereas cellular NADH and FAD levels are reliably detectable as autofluorescence, quantifying cellular ROS production is more demanding, because the various redox-sensitive dyes share major disadvantages including irreversible oxidation, autooxidation and photosensitivity.
However, its disadvantages are also very apparent, such as its high cost, its low throughput, and its limited detectable depth, which is a particular hindrance in whole-body analysis.
The disadvantage of this technique is that the number of broken wires needed to cause a detectable variation in the external diameter can be significant.
