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Individual deletions of these RL proteins cause no detectable defects, suggesting a dominant role of RHD3 (Zhang et al., 2013).
In mouse, Eaf2/U19 gene-targeting did not cause any detectable defects in embryos [10].
Injection of the same amount of control MO did not produce any detectable defects.
The survivors were scored as unimpaired (alive with no detectable defects in morphology, behavior, or motility using a standard stereomicroscope), or impaired (alive but with detectable defects in morphology, behavior, or motility).
In contrast, Chiang et al. [47] have reported that mTERT+/− heterozygotes had no detectable defects in telomere elongation compared with wild-type controls.
In particular there were no detectable defects in epithelial cells with respect to the cortical actin (Fig. 2D and data not shown) and in midline glia where dGIPC is expressed at high levels.
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This equates to a minimum detectable defect size of about 0.2 mm for a Hastelloy X slab thickness of <2 mm.
After hydrogen intercalation, we show that the resulting QFMLG is relieved from the periodic corrugation and presents no detectable defect sites.
Mice with XIAP deletion are normal and have no detectable defect in apoptosis with a compensating up-regulation of c-IAP1 and c-IAP2 (Harlin et al., 2001), while mice with deletion of cIAP1 in combination with cIAP2 or XIAP show embryonic lethality due to cardiovascular defects (Moulin et al., 2012).
Cells showing these dynamic helical conformations divided without detectable defect.
Because the mRNA export pathway is highly robust and redundant, we speculated that inhibition of Ccr4-Not alone may not result in a detectable defect in global mRNA export.
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