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After accounting for likelihood of statin use by including a propensity score in each model, there was no detectable benefit of either prior (adjusted OR, 0.9; 95% CI, 0.63 1.29; P = 0.57) or continued statin use (adjusted OR, 0.73; 95% CI, 0.47 1.13; P = 0.15).
Psychology professor and study co-author Elizabeth Dunn echoed Dwyer's findings, saying that there's a "real and detectable benefit from putting your phone away" during social situations.
Overall, treatment of both MPS IIIA and GM1 mice with CD showed no detectable benefit in reduction of either cholesterol or GSL storage.
These results demonstrated that while the inflammatory status of the adipose tissue could be moderately altered by bone marrow-derived JNK1 deficiency, this is insufficient to yield a detectable benefit on systemic insulin sensitivity when the parenchymal cells are intact at the JNK1 locus, under the experimental conditions and assays utilized in this study.
We then investigated the same product in a rigorous double-blind, randomized controlled trial (RCT) to ascertain whether or not its use results in a clinically detectable benefit.
The main reason for a lack of detectable benefit was the magnitude and duration of improvement from the baseline level at trial entry.
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These results suggest that GDNF is more effective than BDNF for correcting the rat model of PD, and that there are no detectable benefits from expressing both of these neurotrophic factors.
Compared with placebo, the average symptom improvement may not reach clinically noticeable levels though some men may achieve detectable benefits and/or have symptom progression prevented.
In addition, for colon cancer, screening strategies in usual care are likely to eliminate detectable benefits or reduce the incidence of disease and thereby lead to large sample size necessary to detect differences in outcomes in a prevention trial.
Numerous large clinical trials demonstrated the beneficial effects of RAS blockade on clinical symptoms and outcomes of patients with CKD; however, marked interindividual variability were detected in response to these treatments ranging from recognizable clinical benefit to non-detectable benefits or even serious adverse effects [12, 13].
It is well accepted that a sufficient hypoxic dose (h/day; number of days; degree of hypoxia) is required to induce detectable erythropoietic benefit.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com