Sentence examples for detectable appearance of from inspiring English sources

Here, we demonstrate that ablation of c-RAF expression in advanced tumors driven by KrasG12V/Trp53 mutations leads to significant tumor regression with no detectable appearance of resistance mechanisms.

Furthermore, accumulation of ssDNA preceded the detectable appearance of DSBs, suggesting that ssDNA formation at replication forks is a precursor to chromosome breakage at those locations.

The forward primer designed for amplification of the Actin2 was intron spanning; thus, genomic DNA contamination in the sample was detectable by the appearance of a DNA band at 291 bp.

Interestingly, the time lapse between the detection of the PFSPs and the appearance of detectable pSer129-reactive inclusions suggests that some populations of PFSPs remain below detectable levels or that the PFSPs were able to initiate the seeding or slow formation of αS inclusions before being degraded.

Model experiments suggest that the appearance of detectable concentrations of this radical result from a disturbance of the normal state of the ascorbic acid, dehydroascorbic acid redox system.

Moreover, the same location could be imaged on separate occasions with no detectable change in the appearance of the fluorescence or reflectance images.

This differential adaptive capacity likely underlies the more rapid appearance of detectable skeletal changes in OA in comparison to the articular cartilage.

In three different experimental paradigms (orthotopic tumor cell line allografts, tumor transplantation, and de novo tumor development), the appearance of detectable MMTV-PyMT mammary tumors is significantly delayed in the NG2 null mouse.

A complete response (CR) required complete disappearance of all previously detectable disease with no appearance of new lesions, and partial response (PR) required at least a 50% decrease of the sum of the products of the two greatest perpendicular diameters of all measurable lesions, with no appearance of new lesions or progression of any lesion.

The finding of a rapid onset of tumour endothelial apoptosis, occurring before the appearance of detectable TNF in tumour tissue (Ching et al, 1999), suggests that DMXAA exerts a direct effect on tumour vasculature, and is of particular relevance to clinical trials.

5 Moreover, should the incubation period for prion disease be considerably longer in people with different genotypes, uncertainty about the timing of the appearance of detectable PrPCJD in these will increase, with concomitant implications for the interpretation of results of PrPCJD prevalence surveys.