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The study design has adequate power to detect reductions in mortality rate equal to 25% of the projected baseline mortality rate for both of the interventions.
This paper presents a novel protocol that demonstrates sufficient sensitivity to detect reductions in soft tissue motion during landings in high compression garments compared to no compression.
Although falciparum malaria kills more than one million children each year, single centers cannot enroll enough patients to detect reductions of 20 30% in mortality rates.
It is important to note that the NMN ELISA has adequate sensitivity to detect reductions in enzymatic activity beyond those associated with the HPS haplotype.
Third, we used the M-ratio test implemented by Garza and Williamson [36], which uses the statistic M (the ratio of the number of alleles to range in allele size) to detect reductions in effective population size for a sample of microsatellite loci.
Use of brain tissue oxygen and thermodilution CBF probes to detect reductions in perfusion related to excessive lowering of BP is gaining in popularity.
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However, we did not detect reduction of PTEN expression in cultures of pseudotyped HIV-1 infected cells or after macrophage treatment with HIV-1 Tat (Figure 4A).
Using the 0 48 hour fecal weight of 12040 g (SD 2751 g), enrolling 25 patients per study arm would provide 90% power to detect reduction in fecal weight by 3010 g (25% reduction) at the two sided 0.025 significance level.
Strengths of our study design include the randomized allocation of interventions, the laboratory-based outcome measures, and our demonstrated ability to observe secondary infections with the implied potential to detect reduction in secondary attack ratios.
These findings are in accordance to our present data, as we detected a small, but highly significant increase in GRN promoter methylation, although we could not detect reduction in GRN mRNA expression.
Consequently, this biosensor indeed allows analyzing changes from low to high oxygen concentrations but it cannot directly be used to detect reduction of oxygen levels via its change of intramolecular FRET efficiency.
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