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Disease-specific instruments have the capacity to detect minimal changes in a specified health condition [ 3].
RPPA is a robust platform able to detect minimal changes in protein levels [ 15].
While the advantage of using cancer-specific instruments is their capacity to detect minimal changes in a disease, these instruments are not suitable for comparisons across different disease states.
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Indeed, a well-performed MRI is more sensible in detecting minimal changes in size than a simple CT evaluation.
The strengths of the study were the precise study design, investigation of relevant parameters (PK, safety, and efficacy) in the investigated patient population, and the use of highly sensitive GC/MS to detect minimal changes of systemic estrogen concentrations.
Interestingly, the authors detected only minimal changes in the levels of lipids, lipoproteins, and apolipoproteins in response to normal food intake in the general population, which raises the issue of what might convey the increased postprandial CVD risk.
While we might have expected a decline in TEER even at 24 h this is not surprising since characteristically relatively low TEER values commonly obtained (with few exceptions) in Transwell setups may not provide enough sensitivity to detect minimal yet significant changes in paracellular permeability.
Nevertheless, more than often the MCID is used in the context of a treatment effect, thus the MCID results in our study can still be applied to detect minimal clinically improvement in score changes.
This is supported by the fact that E. coli K92 produced large amounts of CA at 19°C in contrast to 37°C, but minimal changes in cps transcription were detected [ 21], suggesting that post-transcriptional modifications take place.
Minimal changes in anti-Ro and anti-La titer were detected in the CLTA4IgG-treated mice compared with the AAV2-LacZ-treated mice.
Likewise, minimal changes in the activity status of Akt or AMPK were detected in skeletal muscle extracts from AKAP150Δ36 mice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com