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A second aim of this review is to demonstrate that the conventional design of teratology studies is not optimal to detect malformations caused by IKr blocking drugs.
Using a post hoc sample size calculation, we find that our study had greater than 95% power to detect malformations and greater than 99% power to detect malformations/disorders.
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Fetal magnetic resonance imaging (MRI) complements ultrasonography, confirming the suspected anomaly and even detecting malformations that were not detected at ultrasonography.
The neonatal examination confirmed all the sonographically detected malformations.
Somewhat unexpected, we detected malformations of the ISVs and a reduced capacity of iLECs to separate from the CV in Ccbe1+/− embryos.
MRI is the best diagnostic tool for detecting malformations such as cochlear nerve hypoplasia or aplasia, and it is the best screening tool for early cochlear ossification following bacterial meningitis [ 26, 27].
These parents received information about a detected malformation with unclear significance, and it was impossible for doctors and midwives to provide clarity and predict the outcome.
These studies detect fetal malformations, which may or may not be drug-related adverse events.
Ultrasonography is performed to detect possible malformations at about 20 weeks into gestation.
Some midwives suggested that the pregnant woman had an antenatal ultrasound investigation in order detect foetal malformations before birth.
Accordingly, invasive cardiac catheterization and cardiac ventriculography are no longer needed to detect cardiac malformations and functional anomalies [ 43].
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