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Although our assays did not detect impairment of catalytic activity, they do not exclude the possibility of impaired enzyme function in vivo.
Trail tests detect impairment in psychomotor speed and mental flexibility, both domains that are often impaired in HE [ 3]. Results are expressed in seconds.
Positron emission tomography (PET) can detect impairment of dopaminergic function in living brain.
However, we did not detect impairment in estrus expression, estrus duration or ovulation (P > 0.05).
Patients with chronic CH had significantly greater impairment in their QoL compared to their episodic counterparts (61.6 ± 18.9 vs 56.2 ± 19.0, p = 0.010), further supporting good validity and sensitivity of the questionnaire to detect impairment specifically related to CH.
Detailed history taking from family members to elicit behavioural features underpins the diagnostic process, with support from neuropsychological testing designed to detect impairment in decision making, emotion processing, and social cognition.
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A subset of these animals was trained on a win-shift radial maze task, designed to detect impairments in hippocampal-dependent memory.
In practice, impairments in physical functioning can be used by healthcare professionals to detect impairments in other domains.
Thus we expect to detect impairments in any phase of memory processing, including formation, consolidation and retrieval.
Consistent with the blood glucose measurements, the breath test was able to detect impairments in clearance of exogenous (oral) glucose from circulation in individuals with PDED.
Despite the small numbers it is difficult to argue for inadequate sensitivity of the task since we were able to detect impairments in accuracy on the control condition.
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