Sentence examples for detect efficacy from inspiring English sources
Such errors can have a very important impact on drug development in that, if carried through to the Phase 2 and Phase 3 studies, we can significantly increase the probability of failure to detect efficacy as a result of having delivered an inadequate dose.
Second, as this was a pilot trial, our sample size was small and not powered to detect efficacy of the intervention.
"It would not only jeopardize the chances of the ring vaccination trial having sufficient power to show efficacy but also, unless NIH was prepared to increase the size of their trial very substantially, the NIH trial would have little or no power to detect efficacy".
Gradual enrolment of participants drastically reduces the power to detect efficacy compared with immediate rollout.
Figure 2C shows that there is low power to detect efficacy when adjusted by the extinction probability.
We simulate trials under these forecasts and test potential start dates and rollout schemes to assess power to detect efficacy, and bias in vaccine efficacy estimates that may be introduced.
Researchers might also have trouble detecting efficacy if a vaccine offers only partial protection, NIAID's Mascola says.
Among those who had drug levels detected, efficacy was above 90%% [ 3, 32].
The CGI-SCH may be as sensitive as the BPRS in detecting efficacy differences between antipsychotic drugs [ 12], but it is necessary that treatment response be interpreted in the context of patient characteristics [ 13].
The sample size for the primary endpoint was estimated on the basis of an assumed influenza attack rate of 4% of culture-confirmed influenza disease (type A and/or B) among placebo recipients, a vaccine efficacy (VE) of 70%, and 90% power to detect vaccine efficacy with a lower limit of the 95% CI for efficacy >45% with alpha = 0.025 (1-sided).
The proposed strategy could be employed for in situ monitoring of the change of intracellular telomerase activity in response to drugs to detect drug efficacy.
