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While the statistical analyses of [oxy-Hb] detected activation laterality in the angular/supramarginal gyri and roughly similar trends in both [oxy-Hb] and [deoxy-Hb] results were observed in the bar graphs (Fig. 5), the statistical analyses of [deoxy-Hb] did not detect critical differences in activations between LH and RH.
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"What made the critical difference in this event?
Biddle did not always prevail, but he made a critical difference in our nation's policies.
Because no two biologic medicines are identical, postapproval safety monitoring will be critical to detect potential differences in safety signals between a biosimilar, its reference product, and other biosimilars.
However, as recommended by the ICH S6 (R1) guideline, tissue cross-reactivity studies with mAbs should not be used to assess the comparability because these studies are insufficiently powerful to detect the subtle differences in critical quality attributes.
"A well-trained operator can detect subtle differences in how the plant is operating.
Fat is often reported as being creamier, and some supertasters can detect tiny differences in the fat content of milk.
Can otologic surgeons detect the differences in the resultant prostheses?
Can otologic surgeons detect the differences in the resultant prostheses? .
For example, research shows that our nervous system is designed to observe and detect subtle differences in our environment.
Analysis of large populations will be critical to identify if there is a systemic risk to these intravitreal agents, as individual trials are not powered to detect differences in uncommon events.
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