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In the GSATools approach, the g_sa_analyze scans the protein to detect contributions to a functional change by local motions.
Hence, ASAXS data may be used to detect contributions to the scattering intensity that are due to fluctuations.
However, a problem with inferring the presence of pleiotropy is the generally low statistical power to detect contributions from alleles of small phenotypic effect (Wagner and Zhang 2011; Hill and Zhang 2012b; Paaby and Rockman 2013), such as those observed in this experiment.
Two other studies have used the same fate mapping model to investigate postnatal cardiomyogenesis (Hsieh et al, 2007; Loffredo et al, 2011); however, they were designed primarily to detect contributions by endogenous progenitors to the myocyte pool, not proliferation of resident myocytes.
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However, our Instruct analysis did not detect contribution of other Oryza groups to BHA weedy rice, and we have no a priori reason to believe our aus sampling did not capture the genetic diversity present in this geographically limited group.
Together with the fact that overall PSEA more efficiently detected contribution from the more abundant population (i.e. granule cells, see above), we concluded that expression contribution by cell populations of lower abundance could effectively be masked by expression in a more abundant cell population.
A land use transfer matrix was used to detect critical contributions leading to the LST variations.
Perhaps the dilution in relatively large cells was too effective to detect modest contributions of tracer through preferential flow paths.
While these analyses were conducted on a convenient sample, our sample sizes were adequate to detect meaningful contributions of each variable at 80% power [ 9].
We cannot exclude that small sample sizes and seed contamination (as inferred by the observed heterogeneity of several variety samples) may have limited our ability to detect genetic contributions of some varieties to the feral populations.
Furthermore, a small sample size can frequently result in insufficient power to detect minor contributions of one or more alleles [ 30] – as we observed with the results from the SEARCH sample.
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