During a study aimed at detecting connections between genotype and response to triptans administration, we characterized a CM population for polymorphisms in the genes coding for monoamine oxidase A, g-protein beta 3 and the cytochromes CYP3A4 and CYP1A2.
Three-dimensional methods are capable of detecting connections between the structure and biological characteristics not captured by 2D methods and vice versa.
Besides the NCAPG – MRVI1 correlation of additive effects, we further detected connections between NCAPG, follicle stimulating hormone receptor (FSHR) and glutamate receptor, ionotropic, kainate 2 (GRin2) in the NCAPG sub-network.
Although this is partially overcome by discarding compounds active in several assays of the same project and consequently, performed in similar experimental backgrounds (filter F3), our approach also detects connections between cell-free assays that are apparently unrelated.
Given the previously detected connection between CSN and human neurological disorders, our model study is the first step in understanding of its mechanism.
The frequency of connections between pairs >100 µm apart did not change significantly with age, indicating that the decline did not reflect decreased ability to detect connections in older mice.
We detect connections (synapses) between neurons using geometric proximity tests.
As expected, for K > 200, it properly detects connectivity between adjacent structures with zero observed FNs for all pairs of existing connections.
Synaptophysin was used as a marker of synapse to detect synaptic connections between newly formed neurons.
One goal of the approach was to detect functional connections between disease and drug action.
Ingenuity Pathway Analysis (IPA; Ingenuity® Systems, http://www.ingenuity.com) was used to gain insight into functions of, and to detect potential connections between, the 75 genes whose expression was correlated with differential milk yield.
