Third, and perhaps most convincing, for about 10% of the known enzyme specificities, isofunctional proteins without detectable sequence or structure similarity have been detected, an indication that multiple, independent solutions to the same biological function are accessible to evolution [ 16, 17].
Our results do not seem to suffer from this bias, as we did not detect any indication of an overinflated inbreeding coefficient in the immigrants group, who likely have alleles that are "rare" in the isolated and endogamous island population.
We did not detect any indication of major dose escalation in our cohort during the follow-up period.
These leopard populations have not evolved in isolation due to genetic drift, and we did not detect any indication of this population having gone through any severe population decline leading to a genetic bottleneck.
Unsurprisingly we could not detect any indication of the involvement of the insulin pathway, either up- or down-stream of the insulin receptor, but instead observed an up-regulation of known inhibitors of insulin-signalling such as Socs3 and Ptprf.
Our intelligence sources in the Damascus area did not detect any indications in the days prior to the attack that opposition affiliates were planning to use chemical weapons.
All covariates were introduced into the logistic regression model to detect any indications of confounding or other associations potentially affecting the primary association between genotypes and endometrial cancer.
Although these results show that caspase-8 is required for 5-FU/TRAIL-triggered apoptosis, we could not detect any indications that 5-FU gave rise to elevated levels of caspase-8, thereby making a role as molecular driver of the observed 5-FU sensitization effect unlikely.
She kept her eye discreetly trained on him, trying to detect a change, any indication at all that he might be nervous about something.
PZA in the presence of positive PZase enzyme from the M. tuberculosis will be converted to POA, which then reacts with ferrous ion to produce a brown colored compound, which can be detected as an indication of positive PZase activity.
We neither detected any indication that the cell was affected by the time-dependent RMS contrast within individual scenes (data not shown).
