Quantitative biochemical methods such as protein-detection in synaptosome- and PSD-fractions cannot detect alterations in specific populations of neurons and are therefore unable to to distinguish broad systemic effects from more subtle changes in neuronal subpopulations.
Among the reported biomarkers (Table 1), one traditional type is immunological detection based on monoclonal/polyclonal antibodies, which often aims to detect alterations in serological molecules from sera of gastric cancer patients (Refs 9, 10, 11, 12).
"We're getting real familiar with the documents," said Jesus I. Solis, an agent on duty one recent afternoon, who voiced confidence that he could detect alterations and forgeries.
The phenomenon that Dr. Wolfe's Pop Art quiz exemplified is known as change blindness: the frequent inability of our visual system to detect alterations to something staring us straight in the face.
With a grant from the Federal Bureau of Investigation, which is interested in ways of authenticating digital images presented in court, Dr. Farid is devising algorithms to detect alterations.
Some of the regulatory mechanisms with which the blood is involved include sensors that detect alterations in temperature, in pH, in oxygen tension, and in concentrations of the constituents of the blood.
The advantage of using DDR foci as functional biomarkers is that they can detect alterations in DNA repair due to various mechanisms.
This review concludes by discussing problems occurring during electrospray that can adversely affect the functional properties of biomolecules, along with techniques to detect alterations in their properties and recommendations to prevent such changes.
Moreover, we estimated the effect size of the differences in the executive performance between polysubstance users and non substance users in order to know which neuropsychological tasks can be useful to detect alterations in the executive functions.
Participants at this meeting identified and examined methods to detect alterations in thyroid hormone synthesis, transport, and catabolism.
DTI with tractography reconstruction can accurately detect alterations of involved nerve fascicles, such as displacement, stretching, bowing, or rupture (Fig. 18).
